Endocrine Abstracts

Infants rarely present with truly ambiguous genitalia and such children should be evaluated by experts who work within a multidisciplinary team that is dedicated for evaluation and management of children and adults with suspected and confirmed disorders of sex development. The paediatric endocrinologist who is a vital, and often, the central member of this clinical team needs to lead the clinical evaluation of the infant systematically but also needs to be sensitive to the nee...

BackgroundThere is a need to develop a highly sensitive and reliable immunoassay method for the determination of testosterone concentrations both in children and adults. Testosterone in blood is largely bound to proteins (sex hormone binding globulin and albumin). The unbound fraction of testosterone is considered to be the biologically active hormone which correlates more closely with the physiologically effective level of this hormone. It is postulated...

Background: The use of CSII in children with T1DM is increasing. Several meta-analyses have concluded that there is an improvement in glycaemic control with CSII but most of these investigations have included adults and have been of short duration (<6 months). Our aim was to assess the medium term impact of CSII on HbA1c levels in patients managed with CSII in one region of The UK.Methods: Data was collected retrospectively from 7 centres within Nort...